Early stereological changes in liver of Sprague-dawly rats after streptozotocin injection.Indian Journal of Gastroenterology
Indian Journal of Gastroenterology
2005 vol 24 May-june p,104-107
ISI
5
1- Noorafshan A, Esmailzadeh B, Bahmanpour S, Poost-pasand A
2 4
Background: Diabetes mellitus is associated with
biochemical, physiological and pathologic alterations
in the liver. We measured changes in structure of rat
liver after streptozotocin injection, using stereology.
Methods: Livers of 36 streptozotocin-injected rats
were removed after 4, 8 and 12 weeks. Liver volume
and weight were measured, and volume-weighted mean
volume of hepatocytes and their nuclei were estimated
in periportal (Z1), interstitial (Z2) and perivenous (Z3)
zones of liver acini. Volume of liver sinusoids was
also estimated. Results: Mean volume and weight of
the liver were reduced by 15% and 12%, respectively
at 4 and 8 weeks after injection. Mean hepatocyte
volumes were reduced by approximately 30%, 31%
and 24% in Z1, Z2 and Z3 at 4 weeks, 19% and 24%
in Z2 and Z3 at 8 weeks, and 14% in Z1 at 12 weeks.
Mean volume of hepatocyte nuclei was reduced by
approximately 18% and 20% in Z2 and Z3 at 4 weeks,
23% in all three zones at 8 weeks, and 18%, 15%
and 13% in Z1, Z2 and Z3, respectively, at 12 weeks.
The absolute volume of the sinusoids decreased by
16.5% only at 4 weeks. Conclusion: Streptozotocin
injection leads to early reduction in volume of
hepatocytes, their nuclei and sinusoids in rat liver.
[Indian J Gastroenterol 2005;24:104-107]
دریافت فایل پیوست
Indian Journal of Gastroenterology 2005 vol 24 May-june p,104-107
|
Neuropathological Changes in Brain Cortex and Hippocampus in a Rat Model of Alzheimer’s Disease
. IBJ 15(1 & 2), 51-58. (2011)
15(1 & 2), 51-58. (2011)
ISI
5
Nobakht M, Hosseini, S. M., Mortazavi, P., Sohrabi, I., Esmaeilzade, B
5 7
Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive
abilities and memory loss. The aim of this study was to compare neuropathological changes in
hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing
250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned to three
groups: control, sham and β-amyloid (Aβ) injection. For behavioral analysis, Y-maze and shuttle box were
used, respectively at 14 and 16 days post-lesion. For histological studies, Nissl, modified Bielschowsky and
modified Congo red staining were performed. The lesion was induced by injection of 4 μL of Aβ (1-40) into
the hippocampal fissure. Results: In the present study, Aβ (1-40) injection into hippocampus could decrease
the behavioral indexes and the number of CA1 neurons in hippocampus. Aβ injection CA1 caused Aβ
deposition in the hippocampus and less than in cortex. We observed the loss of neurons in the hippocampus
and cerebral cortex and certain subcortical regions. Y-maze test and single-trial passive avoidance test showed
reduced memory retention in AD group. Conclusion: We found a significant decreased acquisition of passive
avoidance and alternation behavior responses in AD group compared to control and sham group (P<0.0001).
Compacted amyloid cores were present in the cerebral cortex, hippocampus and white matter, whereas,
scattered amyloid cores were seen in cortex and hippocampus of AD group. Also, reduced neuronal density
was indicated in AD group. Iran. Biomed. J. 15 (1 & 2): 51-58, 2011
Keywords: Alzheimer's disease (AD), Hippocampus, β-amyloid (Aβ), Neuropathological changes
دریافت فایل پیوست
IBJ 15(1 & 2), 51-58. (2011)
|
Delivery of Epidermal Neural Crest Stem Cells (EPI-NCSC) to
hippocamp in Alzheimer's Disease Rat Model
Iranian Biomedical Journal
16 (1): 1-9 (January 2012)
ISI
5
Banafshe Esmaeilzade1,2, Maliheh Nobakht*3,4 , Mohammad Taghi Joghataei1, Nahid Rahbar Roshandel5, Homa Rasouli1, Ali Samadi Kuchaksaraei6, Seyed Mohammad Hosseini7, Nowruz Najafzade8, Sara Asalgoo1, Leila Beygom Hejazian1 and Fatima Moghani Ghoroghi1
1 11
Background: Alzheimer’s disease (AD) is characterized by progressive neuronal loss in hippocamp. Epidermal
neural crest stem cells (EPI-NCSC) can differentiate into neurons, astrocytes and oligodendrocytes. The purpose of
this study was to evaluate the effects of transplanting EPI-NCSC into AD rat model. Methods: Two weeks after
induction of AD by injection of Amyloid-β 1-40 into CA1 area of rat hippocamp, Y-maze and single-trial passive
avoidance tests were used to show deficit of learning and memory abilities. EPI-NCSC were obtained from the
vibrissa hair follicle of rat, cultured and labeled with bromodeoxyuridine. When Alzheimer was proved by
behavioral tests, EPI-NCSC was transplanted into CA3 area of hippocamp in AD rat model. The staining of EPINCSC
markers (nestin and SOX10) was done in vitro. Double-labeling immunofluorescence was performed to
study survival and differentiation of the grafted cells. Results: We showed that transplanted EPI-NCSC survive and
produce many neurons and a few glial cells, presenting glial fibrillary acidic protein. Total number of granule cells
in hippocamp was estimated to be more in the AD rat model with transplanted cells as compared to AD control
group. We observed that rats with hippocampal damage made more errors than control rats on the Y-maze, when
reward locations were reversed. Conclusion: Transplanted cells were migrated to all areas of hippocamp and the
total number of granule cell in treatment group was equal compared to control group. Transplantation of EPI-NCSC
into hippocamp might differentiate into cholinergic neurons and could cure impairment of memory in AD rat
model. Iran. Biomed. J. 16 (1): 1-9, 2012
Keyword: Alzheimer’s disease, Cholinergic neuron, Hair follicle
دریافت فایل پیوست
Iran. Biomed. J. 16 (1): 1-9, 2012
|
The Role of Biodegradable Engineered Nanofiber Scaffolds Seeded
with Hair Follicle Stem Cells for Tissue Engineering
Iranian Biomedical Journal
16 (4): 193-201 (October 2012)
ISI
5
Leila Beigom Hejazian1,2, Banafshe Esmaeilzade3, Fatima Moghanni Ghoroghi1, Fatemeh Moradi1, Marzieh Beigom Hejazian4, Anahita Aslani5, Mehrdad Bakhtiari1, Masoud Soleimani6 and Maliheh Nobakht*7,8
2 9
Background: The aim of this study was to fabricate the poly caprolactone (PCL) aligned nanofiber scaffold and to
evaluate the survival, adhesion, proliferation, and differentiation of rat hair follicle stem cells (HFSC) in the graft
material using electrospun PCL nanofiber scaffold for tissue engineering applications. Methods: The bulge region
of rat whisker was isolated and cultured in DMEM: nutrient mixture F-12 supplemented with epidermal growth
factor. The morphological and biological features of cultured bulge cells were observed by light microscopy using
immunocytochemistry methods. Electrospinning was used for production of PCL nanofiber scaffolds. Scanning
electron microscopy (SEM), 3-(4, 5-di-methylthiazol- 2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, and
histology analysis were used to investigate the cell morphology, viability, attachment and infiltration of the HFSC
on the PCL nanofiber scaffolds. Results: The results of the MTT assay showed cell viability and cell proliferation
of the HFSC on PCL nanofiber scaffolds. SEM microscopy images indicated that HFSC are attached, proliferated
and spread on PCL nanofiber scaffolds. Also, immunocytochemical analysis showed cell infiltration and cell
differentiation on the scaffolds. Conclusion: The results of this study reveal that PCL nanofiber scaffolds are
suitable for cell culture, proliferation, differentiation and attachment. Furthermore, HFSC are attached and
proliferated on PCL nanofiber scaffolds. Iran. Biomed. J. 16 (4): 193-201, 2012
Keywords: Nanofiber, Electrospinning, Stem cells, Tissue engineering
دریافت فایل پیوست
Iran. Biomed. J. 16 (4): 193-201, 2012
|
Evaluation of the Effect of NT-3 and Biodegradable
Poly-L-lactic Acid Nanofiber Scaffolds on Differentiation
of Rat Hair Follicle Stem Cells into Neural Cells In Vitro
J Mol Neurosci
(2013) 51:318–327
ISI
5
Fatemeh Moghani Ghoroghi & Leila Beygom Hejazian & Banafshe Esmaielzade & Masumeh Dodel & Masoud Roudbari & Maliheh Nobakht
3 6
Recent improvement in neuroscience has led to
new strategies in neural repair. Hair follicle stem cells are
high promising source of accessible, active, and pluripotent
adult stem cells. They have high affinity to differentiate
to neurons. Aside from using cell–scaffold combinations
for implantation, scaffolds can provide a suitable
microenvironment for cell proliferation, migration, and differentiation.
NT-3 is the most interesting neurotrophic factors
being an important regulator of neural survival and
differentiation. Since treatment duration in neural repair is
very important, this study aims to evaluate the effect of NT-
3 and poly-L-lactic acid (PLLA) on differentiation time of
bulge stem cells of rat hair follicle to neural-like cells.
HFSCs of rat whisker was isolated and cultured on PLLA
and differentiated with 10 ng/mL NT-3. Biological features
of cultured cells were evaluated with immunocytochemistry
and flowcytometry methods by using CD34, nestin, and
βІІІ-tubulin markers. For cell viability and morphological
assessment, MTT assay and SEM were performed. Our
results showed that bulge stem cells of hair follicle can
express CD34 and Nestin before differentiation. By using
NT-3 during differentiation process, the cells showed positive
reaction to βІІІ-tubulin antibody. MTT results demonstrated
that PLLA significantly increased cell viability.
Finally, HFSCs adhesion was confirmed by SEM results.
The results indicate that 10 ng/mL NT-3 and PLLA have
significant effect on differentiation time of rat HFSCs to
neural cells even in 10 days.
Keywords Bulge . Hair follicle stem cell . CD34 . Nestin .
βІІІ-tubulin . NT-3 . Scaffold PLLA
دریافت فایل پیوست
J Mol Neurosci (2013) 51:318–327
|
Effect of Neurotrophin-3 on differentiation of rat hair follicle stem cells into
neural like cells
Journal of Iranian Anatomical Sciences
Vol 9, No 37, Winter 2012, page 269-278
علمی پژوهشی
3.5
Moghani Ghoroghi F., M.Sc*, Nobakht M., Ph.D., Esmaeilzade B., M.Sc., Bakhtiyari M., Ph.D., Hejazian L.B., M.Sc.
3 5
Purpose: The aim of this study was to evaluate the effect of NT-3 on the decrease of the
differentiation time of bulge stem cells of rat hair follicle from neuron like cells.
Materials and Methods: The bulge region of the rat whisker was isolated from and cultured in
DMEM/F12 supplemented with epidermal growth factor (EGF) in 3 groups for 7,8 and 9 days .
Then 10 ng /ml NT-3 was added to each group for 3 days. Finally, cell differentiation was assessed
by immunocytochemistry using βⅢ-tubulin antibody and the result was compared with control
groups.
Results: According to our results hair follicle bulge stem cells expressed CD34 and Nestin in 7-9
and 10-12 first days after cultivation respectively. By using NT-3 duration differentiation process
the cells showed positive reaction to βⅢ-tubulin antibody.
Conclusion: The results indicate that NT-3 can affect on differentiation speed even in less than 10
days.
Key Words: Bulge of hair follicle, CD34, Nestin, NT-3, βⅢ-tubulin
دریافت فایل پیوست
Journal of Iranian Anatomical Sciences, Vol 9, No 37, Winter 2012, page 269-278
|
Neuronal Differentiation of Rat Hair Follicle Stem Cells: the
Involvement of the Neuroprotective Factor Seladin-1 (DHCR24)
Iranian Biomedical Journal
18 (3): 136-142 (July 2014)
ISI
5
Samira Gilanchi1,2, Banafshe Esmaeilzade1,3, Akram Eidi2, Mahmood Barati4, Soraya Mehrabi5, Fatima Moghani Ghoroghi6 and Maliheh Nobakht*1,6,7
2 7
Background: The seladin-1 (selective Alzheimer disease indicator-1), also known as DHCR24, is a gene found to
be down-regulated in brain region affected by Alzheimer disease (AD). Whereas, hair follicle stem cells (HFSC),
which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is
the predominant source of seladin-1. Our aim was to evaluate seladin-1 gene expression in hair follicle stem cells.
Methods: In this study, bulge area of male Wistar rat HFSC were cultured and then characterized with Seladin-1
immunocytochemistry and flow cytometry on days 8 to 14. Next, 9-11-day cells were evaluated for seladin-1 gene
expression by real-time PCR. Results: Our results indicated that expression of the seladin-1 gene (DHCR24) on
days 9, 10, and 11 may contribute to the development of HFSC. However, the expression of this gene on day 11
was more than day 10 and on 10th day was more than day 9. Also, we assessed HFSC on day 14 and demonstrated
these cells were positive for β-ш tubulin, and seladin-1 was not expressed in this day. Conclusion: HFSC express
seladin-1 and this result demonstrates that these cells might be used to cell therapy for AD in future. Iran. Biomed.
J. 18 (3): 136-142, 2014
Keywords: Seladin-1 (selective Alzheimer disease indicator-1), Alzheimer disease (AD), Hair follicle stem cells
دریافت فایل پیوست
Iran. Biomed.
J. 18 (3): 136-142, 2014
|
Adult neurogenesis of epidermal neural crest stem cells
(EPI-NCSC) in hippocampus of Alzheimer's rat model
Comp Clin Pathol
scopus
3.5
Banafshe Esmaeilzade & Maliheh Nobakht & Seyed Mohammad Hosseini & Pejman Mortazavi & Mahmood Barati & Soraya Mehrabi & Leila Beygom Hejazian & Fatima Moghani Ghoroghi
1 8
Abstract Alzheimer’s disease (AD) is characterised by progressive
neuronal loss in the hippocampus. Our aim was to
evaluate the effects of transplanting epidermal neural crest
stem cells (EPI-NCSC) into the hippocampus in vivo and to
assess adult neurogenesis and total granule cell number in
the hippocampus of an Alzheimer’s rat model after a single
injection of EPI-NCSCs. Fourteen days after a bilateral
injection of β-amyloid 1–40 into the hippocampus, 10 AD
model rats received an intra-hippocampal injection of EPINCSCs;
the cells were obtained from the vibrissa hair follicle
of the rat, cultured, labelled with bromodeoxyuridine
(BrdU) and suspended in normal saline. Y-Maze and single
trial passive avoidance tests were used to show any learning
and memory deficit. Nestin staining was performed in vitro.
Double staining of BrdU–GFAP and BrdU–βІІІ was undertaken
to study survival and differentiation of the grafted
cells. Cell proliferation and differentiation were observed
in all part of hippocampus in the double-stained histological
sections. Total granular cell number was estimated to be
more per hippocampus in the rats receiving the transplanted
cells compared to the AD control group. We observed that
rats with hippocampal damage made significantly more
errors than control rats on the Y-maze. We showed that
transplanted EPI-NCSCs survived and differentiated into
neurons and glial cells. Total granule cell number in the
treatment group was equal to the control group. Cell proliferation
and migration tends to end in the dentate gyrus and
the other part of hippocampus. Transplantation of EPINCSCs
into the hippocampus might differentiate into neurons
or induce neurogenesis.
Keyword EPI-NCSCs . Alzheimer’s disease . Granule cell
number . Neurogenesis . Hippocampus
دریافت فایل پیوست
|
Hair follicle stem cells: In vitro and in vivo neural
differentiation
World J Stem Cells
2015 June 26; 7(5): 866-872
pubmed
5
Nowruz Najafzadeh, Banafshe Esmaeilzade, Maryam Dastan Imcheh
2 3
Hair follicle stem cells (HFSCs) normally give rise to
keratinocytes, sebocytes, and transient amplifying
progenitor cells. Along with the capacity to proliferate
rapidly, HFSCs provide the basis for establishing a
putative source of stem cells for cell therapy. HFSCs are
multipotent stem cells originating from the bulge area.
The importance of these cells arises from two important
characteristics, distinguishing them from all other adult
stem cells. First, they are accessible and proliferate for
long periods. Second, they are multipotent, possessing
the ability to differentiate into mesodermal and
ectodermal cell types. In addition to a developmental
capacity in vitro , HFSCs display an ability to form
differentiated cells in vivo . During the last two decades,
numerous studies have led to the development of an
appropriate culture condition for producing various cell
lineages from HFSCs. Therefore, these stem cells are
considered as a novel source for cell therapy of a broad
spectrum of neurodegenerative disorders. This review
presents the current status of human, rat, and mouse
HFSCs from both the cellular and molecular biology
and cell therapy perspectives. The first section of this
review highlights the importance of HFSCs and in vitro
differentiation, while the final section emphasizes the
significance of cell differentiation in vivo .
Key words: Hair follicle; Stem cells; Bulge area; Neuron;
Differentiation
دریافت فایل پیوست
World J Stem Cells 2015 June 26; 7(5): 866-872
ISSN 1948-0210 (online)
|
the cytotoxic effects of acute dose of aluminum chloride on renal filtration barrier in rabbit
The 8th Iranian anatomical sciences congress (16-19 May, 2008 Tehran/Iran
Bazzy p, Esmaeilzade B, Akbarzadeh S, Zarea A
2 4
دریافت فایل پیوست
|
بررسي اثر نوروتروفين 3 بركاهش زمان تمايز سلولهاي بنيادي فوليكول موي موش صحرائي به نورون
The 10th Iranian anatomical sciences congress (9-11 May, 2012 Guilan/Iran)
مليحه نوبخت*، فاطمه مغني قرقي، مهرداد بختياري، بنفشه اسماعيل زاده، ليلا بيگم حجازيان
4 5
مقدمه: با توجه به پيشرفت هاي جديد در علوم اعصاب و كشت سلولي، درمانهاي جديد براي ترميم عصبي پيش رو قرار
گرفته است. در اين راستا استفاده از سلولهاي بنيادي براي تمايز به نورونها مورد توجه قرار گرفته اند. براي اين منظور استفاده
فوليكول موبه دليل دسترسي آسان و چند ظرفيتي بودن و نداشتن موارد bulge از سلولهاي بنيادي بالغ موجود در ناحيه
نيز به عنوان يكي NT- اخلاقي سلولهاي بنيادي جنيني و پتانسيل تمايز به سلولهاي عصبي از اهميت ويژه اي برخوردارند. 3
از فاكتورهاي تروفيك شناخته شده سيستم عصبي به جهت ايفاي نقش مهم تسهيل در زنده ماندن و تمايز نوروني در طي
تكامل بسيار مورد توجه مي باشد. از آنجائيكه كوتاه كردن زمان ترميم عصبي فاكتور بسيار مهمي در روند درمان مي باشد،
فوليكول مو به نورون مي باشد. bulge بر كاهش زمان تمايز سلولهاي بنيادي ناحيه NT- هدف از اين پژوهش بررسي تأثير 3
آن كشت داده شد. سلولهاي bulge مواد و روش ها: ابتداء فوليكولهاي ناحيه پشت لب موش صحرائي جداشده و ناحيه
در 3 گروه كشت داده شدند. در اين 3 گروه ، EGF حاوي DMEM/F در محيط 12 bulge بنيادي بدست آمده از ناحيه
با دوز 10 نانوگرم در ميلي ليتر قرار NT- پاساژ در روزهاي 7،8 و 9 انجام شد .سپس هر گروه به مدت 3 روز در مجاورت 3
در اين سه گروه (βⅢtubulin) داده شد. سپس بوسيله تكنيك ايمونو سيتوشيمي تمايز سلولها با آنتي بادي بتاتري توبولين
مورد بررسي قرار گرفت و با گروه كنترل مقايسه شد.
10- و در طي 12 CD 7 روز اول ماركر 34 - فوليكول در 9 bulge نتايج: در اين مطالعه سلولهاي بنيادي بدست آمده از ناحيه
به مدت 3 روز در گروههاي ذكر شده همزمان با روند تمايز، NT- روز اول ماركر نستين را بيان كردند. سپس پس از دريافت 3
واكنش مثبت نشان دادند. ( βⅢtubulin) اين سلولها با آنتي بادي بتاتري توبولين
بر تسريع روند تمايز سلولهاي بنيادي فوليكول مو اثر معني داري دارد و NT- نتيجه گيري: با توجه به نتايج اين مطالعه، 3
را به نورون متمايز كند. bulge حتي مي تواند در كمتر از 10 روز سلولهاي بنيادي ناحيه
بتاتري توبولين ،NT- نستين ، 3 ،CD فوليكول مو، 34 ، bulge : واژه هاي كليدي
دریافت فایل پیوست
|
پيوند سلولهاي بنيادي فوليكول مو سبب نوروژنز در هيپوكمپ موشهاي صحرايي نر مدل آلزايمر مي شود
The 10th Iranian anatomical sciences congress (9-11 May, 2012 Guilan/Iran)
بنفشه اسمعيل زاده*، مليحه نوبخت، سيد محمد حسيني، ليلا بيگم حجازيان، فاطمه مغني قرقي
1 5
هدف از اين تحقيق ارزيابي اثر پيوند سلولهاي بنيادي برنوروژنز در هيپو كمپ موشهاي صحرايي مدل آلزايمر بود. با تزريق
1 درهيپوكمپ دو طرف موشهاي صحرايي مدل آلزايمر ايجاد شد، 2 هفته بعد از تزريق براي نشان دادن - بتا– آميلوئيد 40
اختلال در حافظه و ياد گيري تست رفتاري انجام شد. سلولهاي بنيادي فوليكول مو از فوليكول موي سبيل موش صحرايي جدا
ليبل شد. بعد از اثبات ايجاد آلزايمر سلولهاي بنيادي فوليكول موبه ناحيه هيپوكمپ پيوند زده شد. مار BrdU كشت داده و با
كرهاي اختصاصي اين سلولها با فلوسايتومتري اندازه گيري شد. با رنگ آميزي ايمونوفلورسانس دو گانه بقا سلولهاي پيوند زده
شده وتمايز آنها به نورون وگلياها نشان داده شد.شمارش سلولهاي گرانولر هيپوكمپ در گروه گيرنده پيوند افزايش معني داري
نسبت به گروه آلزايمر كنترل داشت كه نتيجه گرفته شد علاوه بر تمايز، ناشي از تحريك نوروژنز در هيپوكمپ است .همچنين
مشاهده شد گروه گيرنده پيوند به طور معني داري در تست رفتاري مجدد اشتباهات كمتري نسبت به گروه آلزايمر كنترل
داشت.
واژه هاي كليدي: سلولهاي بنيادي فوليكول مو، بيماري آلزايمر، تست رفتاري ، نوروژنز
دریافت فایل پیوست
|
پيوند سلولهاي بنيادي فوليكول مو سبب نوروژنز در هيپوكمپ موشهاي صحرايي نر مدل آلزايمر مي شود
The 10th Iranian anatomical sciences congress (9-11 May, 2012 Guilan/Iran) oral presentation
: بنفشه اسمعيل زاده*، مليحه نوبخت، سيد محمد حسيني، ليلا بيگم حجازيان، فاطمه مغني قرقي
1 5
هدف از اين تحقيق ارزيابي اثر پيوند سلولهاي بنيادي برنوروژنز در هيپو كمپ موشهاي صحرايي مدل آلزايمر بود. با تزريق
1 درهيپوكمپ دو طرف موشهاي صحرايي مدل آلزايمر ايجاد شد، 2 هفته بعد از تزريق براي نشان دادن - بتا– آميلوئيد 40
اختلال در حافظه و ياد گيري تست رفتاري انجام شد. سلولهاي بنيادي فوليكول مو از فوليكول موي سبيل موش صحرايي جدا
ليبل شد. بعد از اثبات ايجاد آلزايمر سلولهاي بنيادي فوليكول موبه ناحيه هيپوكمپ پيوند زده شد. مار BrdU كشت داده و با
كرهاي اختصاصي اين سلولها با فلوسايتومتري اندازه گيري شد. با رنگ آميزي ايمونوفلورسانس دو گانه بقا سلولهاي پيوند زده
شده وتمايز آنها به نورون وگلياها نشان داده شد.شمارش سلولهاي گرانولر هيپوكمپ در گروه گيرنده پيوند افزايش معني داري
نسبت به گروه آلزايمر كنترل داشت كه نتيجه گرفته شد علاوه بر تمايز، ناشي از تحريك نوروژنز در هيپوكمپ است .همچنين
مشاهده شد گروه گيرنده پيوند به طور معني داري در تست رفتاري مجدد اشتباهات كمتري نسبت به گروه آلزايمر كنترل
داشت.
واژه هاي كليدي: سلولهاي بنيادي فوليكول مو، بيماري آلزايمر، تست رفتاري ، نوروژنز
دریافت فایل پیوست
|